Cefotaxime is an injectable cephalosporin antibiotic used while your pet is hospitalized to treat serious bacterial infections in dogs and cats (ex. acute sepsis, intra-abdominal infections, bone and joint infections, skin and uterine infections). A similar oral drug may have been prescribed to continue therapy once your pet goes home.
WHAT IS THIS DRUG?
- 3rd generation cephalosporin; an antibiotic
- Not approved for use in animals, but can be prescribed legally by a veterinarian as an ‘extra-label’ drug
- Given by intramuscular (in the muscle) or intravenous (in the vein) injection
REASONS FOR PRESCRIBING:
- Used to treat severe or life-threatening bacterial infections, especially susceptible kidney infections
- May also be used to prevent infections in animals having surgery (eg. cesarean sections)
WHAT DOGS/CATS SHOULD NOT TAKE THIS MEDICATION?
- Use with caution in pets with kidney failure
- Use with caution in breeding or pregnant animals. Do not use in nursing animals.
- In human medicine, Cefotaxime is used cautiously in those with a history of gastrointestinal disease, especially colitis
- Pets whom have had previous allergic reactions to penicillin, other cephalosporins or antibiotics
Cefotaxime will be administered to your pet while at the veterinary clinic. This medicine will likely be used for several days while your pet is hospitalized. Your pet may be sent home with an oral antibiotic from the same drug family. Be sure to administer this medication for the entire length of time prescribed by your veterinarian, even if the symptoms improve before the prescription runs out.
Antibiotic medicines can cause diarrhea, which may be a sign of a new infection. Contact your veterinarian if the diarrhea is watery or has blood in it. Do not use any medicine to stop the diarrhea unless your veterinarian has instructed you to do so.
A bacterial culture from the infection may be obtained for testing prior to beginning antimicrobial therapy. Once results become available, another drug may be prescribed if the results show that another antibiotic choice would be more beneficial to your pet.
In 3 or 4 days you should see a response to treatment. If you feel that no improvement has occurred, contact your veterinarian to see if an alternative therapy should be considered.
Laboratory tests may be performed periodically to monitor your pet’s progress or check for side effects.
WHAT IF A DOSE IS MISSED?
STORAGE AND WARNINGS:
Before mixing, the dry powder should be stored at room temperature away from light and moisture.
After mixing, store at room temperature or in the refrigerator. If stored at room temperature, use/discard any remaining solution within 12-24 hours. Refrigerated solution should be used/discarded within 5-7 days of mixing.
Pre-mixed solution can be stored in the freezer until thawing when it can be stored in the refrigerator for up to 10 days. If then stored at room temperature, use/discard thawed solution within 24 hours.
Keep this and all medication out of reach of children and pets.
Call your physician immediately if you accidentally take this product.
Pet owners who are allergic to penicillin and/or other antibiotics should avoid handling this drug.
POTENTIAL SIDE EFFECTS:
- Injection site reactions (pain, inflammation, thickening)
- Rash, itching, fever, allergic reaction
- Vomiting and diarrhea or other gastrointestinal problems
- Rare: heart rhythm abnormalities, blood disorders, altered laboratory test results
- If you notice anything unusual, contact your veterinarian
CAN THIS DRUG BE GIVEN WITH OTHER DRUGS?
Yes, but the following drugs may interact with Cefotaxime: aminoglycosides (eg. gentamicin, neomycin), amphotericin B, anticoagulants, live bacterial vaccines, loop diuretics, polypeptide antibiotics and probenecid.
Contact your veterinarian if pet receives more than the prescribed amount.
WHAT TO TELL/ASK VETERINARIAN BEFORE GIVING MEDICATION?
Talk to your veterinarian about:
- When will your pet need to be rechecked
- What tests may need to be performed prior to and during treatment with this drug
- Risks and benefits of using this drug
Tell your veterinarian about:
- If your pet has experienced side-effects on other drugs/products
- If your pet has experienced digestive upset now or ever
- If your pet has experienced kidney disease now or ever
- If your pet has experienced any other medical problems or allergies now or ever
- All medicines and supplements that you are giving your pet or plan to give your pet, including those you can get without a prescription. Your veterinarian may want to check that all of your pet's medicines can be given together.
- If your pet is pregnant or nursing or if you plan to breed your pet
WHAT ELSE SHOULD I KNOW?
Notify your veterinarian if your animal's condition does not improve or worsens despite this treatment.
This is just a summary of information about Cefotaxime. If you have any questions or concerns about Cefotaxime or the condition it was prescribed for, contact your veterinarian.
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