Cyclosporine is an immunosuppressive drug used to treat immune-mediated diseases, especially blood and skin conditions (ex. atopic dermatitis).
WHAT IS THIS DRUG?
- An immunosuppressive agent
- Given by mouth
REASONS FOR PRESCRIBING:
- Used to treat immune-mediated diseases (ex. immune-mediated hemolytic anemia, discoid lupus erythemathosus in the dog)
- May also be used to treat 'dry eye' (or keratoconjunctivitis sicca/KCS), perineal fistualas, asthma in the cat
- Used to prevent rejection of transplanted organs
WHAT PETS SHOULD NOT TAKE THIS MEDICATION?
- Pets weighing less than 4 pounds or those less than 6 months of age.
- Use with caution in pets with liver or kidney disease
- Pets with malignant neoplasia
- If your pet has had an allergic reaction to cyclosporine
Read and follow the label carefully.
Give this medication without food. Give this medication 1 hour before a meal or 2 hours after. The dose may be tapered by decreasing the frequency of dosing to every other day or 2 times per week until a minimum frequency is achieved that will maintain the desired therapeutic effect.
Cyclosporine tastes bitter. Do not open capsules and give contents by sprinkling on food.
Give this medication for as long as veterinarian directs. Do not skip doses or stop giving the medication without consulting your veterinarian.
Your veterinarian may want to monitor the effects of cyclosporine by performing occasional blood tests.
WHAT IF A DOSE IS MISSED?
If a dose is missed, give it as soon as you can, but do not give more than one dose/day. If it is time already for the next dose, skip the missed dose and go back to the normal schedule. Do not give two doses at the same time.
STORAGE AND WARNINGS:
There are two brands of the oral liquid but they are not the same strength, therefore cannot be subsituted for the other.
Shake oral liquids before using. After opening an oral liquid, use it within 2 months.
If capsules come in a foil blister pack, do not open the pack until ready to use.
Store at room temperature away from heat and direct sunlight. Protect from freezing and do not refrigerate.
Long-term storage in some plastics can cause inactivation of the drug.
Keep this and all medication out of reach of children and pets.
Pregnant owners should avoid handling this drug.
Call your physician immediately if you accidentally take this product.
POTENTIAL SIDE EFFECTS:
- If your pet experiences side effects related to the digestive system (loss of appetite, vomiting, diarrhea), contact your veterinarian. Giving the medication with a small amount of food may be necessary.
- Other side effects may include ear or urinary infections, jaundice, or lethargy.
- More rarely, some pets experience overgrowth of the gums, muscle cramps and increased hair growth. Contact your veterinarian if you notice any of the above signs.
- High doses may cause immune system suppression which may cause your pet to be more susceptible to infection. Contact your veterinarian if your pet has a fever (>103°F), painful urination, fatigue, sneezing, coughing or runny eyes.
CAN THIS DRUG BE GIVEN WITH OTHER DRUGS?
- Yes, but possible interactions may occur with vitamins and supplements, allopurinol, aminoglycosides, amiodarone, amphotericin, androgens, azole antifungals, calcium channel blockers, cimetidine, colchicines, corticosteroids, digoxin, eythromycin, etoposide, metoclopramide, omeprazole, phenobarbital, phenytoin, probucol, rifampin, terbinafine, trimethoprim sulfa, and some vaccines.
- Make sure your veterinarian knows all of the medicines and supplements you are giving your pet or plan to give your pet, including those you can get without a prescription. Do not start, stop or change the dosage of any medicine, including this one, before checking with your veterinarian.
- If your pet experiences any unusual reactions when taking multiple medications, contact your veterinarian.
Contact your veterinarian immediately if your pet receives more than the prescribed amount.
WHAT TO TELL/ASK A VETERINARIAN BEFORE GIVING MEDICATION?
Talk to your veterinarian about:
- When will your pet need to be rechecked
- What tests may need to be performed prior to and during treatment with this drug
- What are the risks and benefits of using this drug
Tell your veterinarian about:
- If your pet has experienced side-effects on other drugs/products
- If your pet has experienced digestive upset now or ever
- If your pet has experienced liver or kidney disease now or ever
- If your pet has experienced any other medical problems or allergies now or ever
- All medicines and supplements that you are giving your pet or plan to give your pet, including those you can get without a prescription. Your veterinarian may want to check that all of your pet's medicines can be given together.
- If your pet is pregnant, nursing or if you plan to breed your pet
WHAT ELSE SHOULD I KNOW?
Notify your veterinarian if your animal's condition does not improve or worsens despite this treatment.
As with all prescribed medicines, Cylcosporine should only be given to the pet for which it was prescribed.
It should be given only for the condition for which it was prescribed.