Dexmedetomidine hydrochloride (Rx)
Dexmedetomidine hydrochloride is a sedative with analgesic properties used in dogs and cats to enable physical exams, various clinical and/or surgical and dental procedures. It may also be given as a premedication prior to general anesthesia in dogs.
WHAT IS THIS DRUG?
- Dexmedetomidine hydrochloride is a synthetic alpha-2-adrenergic agonist with sedative and analgesic properties (non-narcotic)
- Dexmedetomidine hydrochloride is given by intramuscular (in the muscle) and/or intravenous (in the vein) injection in dogs and cats
REASONS FOR PRESCRIBING:
- To produce sedation and analgesia in dogs and cats
- Dexmedetomidine hydrochloride may also be used as a preanesthetic drug, significantly reducing the amount of general anesthesia necessary
WHAT DOGS/CATS SHOULD NOT TAKE THIS MEDICATION?
- Pets with respiratory conditions, heart, liver or kidney diseases
- Pets with diabetes
- Pets in shock, severely debilitated or experiencing stress due to heat, cold or fatigue
- Use in puppies less than 16 weeks, kittens less than 12 weeks and geriatric dogs and cats has not been evaluated
- Use in breeding, pregnant or nursing dogs and cats has not been evaluated
- Pets with known hypersensitivity to alpha2-adrenergic agonists
Dexmedetomidine hydrochloride will be given by your veterinarian and its effects may be later ‘reversed’ with another drug (atipamezole).
Nervous or excited animals should be given 10-15 minutes to calm down after the drug is given to improve the response.
Your pet’s body temperature may decrease during sedation, so keeping your pet warm with towels and/or a hot water bottle may be helpful.
Veterinary staff will frequently monitor respiratory and cardiac function.
Because cats who have received Dexmedetomidine hydrochloride have a reduced blink reflex, an eye lubricant will be applied by veterinary staff to prevent drying of the eyes.
Although Dexmedetomidine hydrochloride provides analgesia more pain management may be required after the procedure has concluded.
WHAT IF DOSE IS MISSED?
STORAGE AND WARNINGS:
Dexmedetomidine hydrochloride should be stored in a cool, dry place at room temperature away from heat and direct sunlight. Protect from freezing.
Keep this and all medication out of reach of children and pets.
Not for human use. Those handling the drug should wear impermeable gloves and handle with care as accidental topical (including ocular), oral exposure or exposure by injection could cause adverse reactions, especially for those with cardiovascular conditions. Call a physician immediately in case of accidental oral intake or self-injection of this product.
POTENTIAL SIDE EFFECTS:
- Handling or any sudden stimuli, including noise, may cause a defense reaction in animal that appears to be heavily sedated
- Rare chance of delayed onset of pulmonary edema (abnormal fluid build-up in air sacs in the lungs). Notify your veterinarian immediately if your cat experiences difficult breathing.
- Reduced heart rate and abnormal rhythms, low blood pressure, pale gums
- Spontaneous muscle twitching, tremors and paddling in some dogs
- Dry corneas due to reduction in blink reflex (especially in cats), easily prevented by an eye lubricant
- Fatigue, anorexia, cystitis in cats
- Decreased respiratory rate and low body temperature
- Contact your veterinarian immediately if you think you pet has a medical problem or side effect from this product's therapy
CAN THIS DRUG BE GIVEN WITH OTHER DRUGS?
- Yes, possible interactions may occur with ACE-inhibitors, anticholinergics, beta-blockers, butorphanol and tricyclic antidepressants
- May adsorb to some natural rubber products
- Dexmedetomidine hydrochloride has not been evaluated in the presence of other sedatives or anesthetics in cats (may cause heart issues)
- If your pet experiences any unusual reactions post-treatment, contact your veterinarian
If an overdose is suspected, reversal with atipamezole will be performed.
WHAT TO TELL/ASK VETERINARIAN BEFORE GIVING MEDICATION?
Talk to your veterinarian about:
- When your pet has last eaten (vomiting may occur post injection)
- When will your pet need to be rechecked
- What tests may need to be performed prior to Dexmedetomidine hydrochloride administration
- Risks and benefits of using this drug
Tell your veterinarian about:
- If your pet has experienced side-effects on other drugs/products
- If your pet has experienced digestive upset now or ever
- If your pet has experienced liver or kidney disease now or ever
- If your pet has experienced any other medical problems or allergies now or ever
- All medicines and supplements that you are giving your pet, including those you can get without a prescription. Your veterinarian may want to check that all of your pet's medicines can be given together.
- If your pet is pregnant or nursing or if you plan to breed your pet
WHAT ELSE SHOULD I KNOW?
Notify your veterinarian if your animal's condition does not improve or worsens despite this treatment.
This is just a summary of information about Dexmedetomidine hydrochloride. If you have any questions or concerns about Dexmedetomidine hydrochloride, contact your veterinarian.