Estrogen - Estradiol cypionate (Rx)
Historically, this drug has been used in dogs to treat urinary incontinence, as well as to prevent embryo implantation in dogs and cats if given within 72 hours of mating.
WHAT IS THIS DRUG?
- A semisynthetic estrogenic hormone
- Tablets are given by mouth, or the injectable form is given by your veterinarian
REASONS FOR PRESCRIBING:
- To treat hormone responsive urinary incontinence in spayed dogs and cats
- To prevent implantation of the fertilized egg in mismatched dogs and cats
- Palliative treatment for benign anal tumors in older male dogs
- To induce estrus (heat cycle)
WHAT DOGS/CATS SHOULD NOT TAKE THIS MEDICATION?
- Animals that may be pregnant (if desired) or nursing (can cause abortions or birth defects)
- Breeding males
- Animals with cancer that may be caused by estrogens, such as mammary (breast) cancer
- Animals with bone marrow disease
- Animals with a known hypersensitivity or allergy to this drug or like drugs should not take this medication
This drug is registered for use in humans and cattle by the Food and Drug Administration but can be prescribed legally to dogs and cats by veterinarians as an extra-label drug.
Read and follow the prescription label carefully.
Give the exact amount prescribed and only as often as directed.
Discuss with your veterinarian if this medication is to be given with food.
Give this medication for as long as your veterinarian directs. Do not skip doses or stop giving the medication without consulting your veterinarian.
Baseline blood work and urinalysis may be recommended to assess your pet’s general health before starting this drug.
Periodic blood work and urinalysis to monitor estradiol cypionate's effect on the body is also advised as long-term therapy is often necessary.
Dose adjustments may be made based upon these results and an assessment of how your dog or cat is responding clinically.
Call ahead for refills.
Ideally, give this medication at the same time(s) daily.
WHAT IF A DOSE IS MISSED?
If a dose is missed, give it as soon as you can. If it is time already for the next dose, skip the missed dose and go back to the normal schedule. Do not give two doses at the same time.
POTENTIAL SIDE EFFECTS:
- This medication, especially at high doses, can affect the gastrointestinal system causing lack of appetite, vomiting and diarrhea
- This medication can affect the reproductive system in unspayed females causing signs of estrus (heat cycle), prolonging estrus, vaginal discharge, uterine infections
- This medication can cause lethargy, an increase in thirst and urination
- This medication can affect the bone marrow resulting in abnormal bruising, anemia, bleeding, and even death
- Use in males may cause feminization
- If these symptoms persist or you notice anything else unusual, contact your veterinarian
CAN THIS DRUG BE GIVEN WITH OTHER DRUGS?
- Yes, but possible interactions may occur when giving estradiol cypionatel in conjunction with: corticosteroids, oral anticoagulants (such as warfarin), ketoconazole, phenobarbital, phenylbutazone, rifampin, some antibiotics (macrolides), tricyclic antidepressants (eg. Clomicalm®) vitamins and supplements
- Drugs other than those listed may also interact with estradiol cypionate
- Do not give new food or medications without first talking to your veterinarian
- If your pet experiences any unusual reactions when taking multiple medications, contact your veterinarian
May cause bone marrow suppression, ovarian tumors, aplastic anemia and death. The heart, liver and pancreas may also be severely damaged.
Contact your veterinarian immediately if your pet receives more than the prescribed amount.
WHAT TO TELL/ASK VETERINARIAN BEFORE GIVING MEDICATION?
Talk to your veterinarian about:
- When your pet will need to be rechecked
- What tests may need to be performed prior to and during treatment with this drug
- What are the risks and benefits of using this drug
Tell your veterinarian about:
- If your pet has experienced side-effects on other drugs/products
- If your pet has experienced digestive upset now or ever
- If your pet has experienced liver or kidney disease now or ever
- If your pet has experienced any other medical problems or allergies now or ever
- All medicines and supplements that you are giving your pet or plan to give your pet, including those you can get without a prescription. Your veterinarian may want to check that all of your pet’s medications can be given together.
- If your pet is pregnant, nursing or if you plan to breed your pet
Storage and Warnings:
Estradiol cypionate should be stored in a childproof container in a cool, dry place at room temperature away from heat and direct sunlight. Avoid freezing.
Keep this and all medication out of reach of children and pets.
Call your physician immediately if you accidentally take this product.
WHAT ELSE SHOULD I KNOW?
Notify your veterinarian if your animal’s condition does not improve or worsens despite this treatment.
As with all prescribed medicines, estradiol cypionate should only be given to the pet for which it was prescribed.
It should be given only for the condition for which it was prescribed.
This is just a summary of information about estradiol cypionate. If you have any questions or concerns about estradiol cypionate or the condition it was prescribed for, please contact your veterinarian.