2001-Wed Oct 17 08:17:41 EDT 2018
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To understand how the strange tumor spreads from devil to devil, one must understand a bit about Tasmanian devil behaviors. Male Tasmanian devils aggressively protect their females against other males. Protection requires “jaw wrestling” to drive off the unsuccessful suitors. In protecting his females, a tumor-affected male can spread the tumor to numerous other males. Devils also may nip each other during communal feedings.
Because the transmission of devil facial tumor occurs through biting, the tumors typically occur in the head and neck region. Autopsies performed on devils who have succumbed to the disease have found that many of the animals died from metastatic cancer that spread to organs throughout their bodies. Devils typically die within a few months of showing visible lesions, as the tumors usually interfere with the animal’s ability to eat and compete for food.
Why the cancer is so contagious is not clear. Some researchers think that, because of their limited genetic diversity, the devils' immune system cannot recognize and destroy the invading cancer cells. However, the immune systems of devils affected by the tumor appear to work normally,adding to the mystery.
The general conclusion is that somehow the clever cancer cells have found a way to evade the devil’s immune response. In essence, they have become "stealth cells," wreaking unchecked havoc throughout the animals' bodies.
Recently, a team of Australian scientists, including veterinary oncologists, investigated the use of a chemotherapy drug successfully used in the treatment of TVT in dogs in Tasmanian devils with facial tumor.
True to their pugnacious nature, the devils tolerated treatment with the drug vincristine at doses much higher than are given to dogs, cats or humans. However, despite their ability to withstand the drug’s toxic effects, no evidence of tumor regression was shown. Hope, for the moment, remains in isolating healthy populations and in the possible future development of an effective vaccine.
We Americans are doing our part to help save the endangered species. Four healthy Tasmanian devils recently swirled into the San Diego Zoo.
Another four have recently taken up residence at the ABQ BioPark Zoo in Albuquerque, N.M.
The devils, who are free of DFT, are part of the Save the Tasmanian Devil Program. They and other captive devils will form the foundation for the reintroduction of devils back into their native habitat should wild devils become extinct because of DFT.
If you happen to be in San Diego or Albuquerque, you can meet the ambassador devils in the zoos’ Australian exhibits. Other top-quality U.S. and international zoos also have been selected as potential “safe sites” for future Tasmanian devil populations. Hopefully, such efforts eventually can help the feisty but endearing “Taz” survive a formidable health challenge.
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