Tribrissen® 400 Oral Paste
Equine Trimethoprim + Sulfonamide
This drug is an antibiotic that fights bacterial infections. This combination antibiotic contains trimethoprim and a sulfonamide, either sulfadiazine or sulfamethoxazole. These two medications work synergistically together which increases their effectiveness against bacteria. This medication is available as an oral paste and an injectable solution.
WHAT IS THIS DRUG?
- A broad spectrum combination antibiotic
- Given by mouth or by intravenous (IV) injection
REASONS FOR PRESCRIBING:
- Used to treat susceptible bacterial infections
- Commonly used for the treatment of wounds, respiratory and uterine infections in horses
Trimethoprim + Sulfonamide should be given according to your veterinarian’s instructions. Read and follow the prescription label and route of administration carefully.
Give the exact amount prescribed and only as often as directed.
Give this medication for as long as your veterinarian directs. Do not skip doses or stop giving the medication without consulting your veterinarian.
Baseline blood work may be recommended to assess your horse’s general health before starting this medication. Periodic blood work to monitor its effects on the body is also advised if long term therapy is necessary.
Dose adjustments may be made based upon an assessment of how your horse is responding clinically.
Ideally, give this medication at the same time(s) daily.
Do not give this medication into the muscle (IM) or under the skin (SQ) as this will cause swelling, pain, and potential tissue damage. Avoid rapid IV injections.
If you are unsure how your horse will react to an injection or oral medication, request assistance or demonstration by your veterinarian.
WHAT IF A DOSE IS MISSED?
If a dose is missed, give it as soon as you can. If it is time already for the next dose, skip the missed dose and go back to the normal schedule. Do not give two doses at the same time.
STORAGE AND WARNINGS:
Trimethoprim + Sulfonamide should be stored in a childproof container in a cool, dry place at room temperature away from heat and direct sunlight.
Keep this and all medication out of reach of children and pets.
Individuals with a known sensitivity to sulfonamides should avoid contact with this medication.
Avoid direct contact with skin, eyes, mouth, and clothing.
Call your physician immediately if you accidentally take this product or if an allergic reaction occurs.
POTENTIAL SIDE EFFECTS:
- There is a risk for antibiotic-associated diarrhea or colic.
- There is a risk for injection site discomfort, swelling, and tissue damage with intramuscular (IM) or under the skin (SQ) injections
- High doses have been reported to cause altered bacterial flora resulting in large intestinal inflammation, abnormal stool, reduced appetite, weight loss, and inactivity
- All antibiotics have the potential to cause an overgrowth of nonsusceptible organisms
- All injectable medications have the potential to cause an immediate allergic or anaphylactic reaction. Affected animals may have a swelling, hives, changes in respiration, and display signs of agitation. This can be a severe and life threatening reaction; immediate treatment with epinephrine is often required.
- There is a risk for a short period of pruritus (itchiness) after IV injections.
- This medication can affect the circulating blood cells causing an anemia (low red blood cells), a thrombocytopenia (low platelets), or a leukopenia (low white blood cells).
- Notify your veterinarian immediately if your horse experiences any adverse reactions to this medication
CAN THIS DRUG BE GIVEN WITH OTHER DRUGS?
- Avoid concurrent use with amantadine, antacids, cyclosporine, digoxin, diuretics, methotrexate, phenytoin, tricyclic antidepressants, and warfarin.
- There is an increased risk for arrhythmias with concurrent use of detomidine, halothane, romifidine, and xylazine.
- Drugs other than those listed may also interact with trimethoprim + sulfonamide
- Do not give new food or medications without first talking to your veterinarian
- If your horse experiences any unusual reactions when taking multiple medications, contact your veterinarian
Contact your veterinarian immediately if your horse receives more than the prescribed amount.
WHAT ELSE SHOULD I KNOW?
Notify your veterinarian if your horse’s condition does not improve or worsens despite this treatment.
This product should not be used in horses intended for human consumption.
Check with the appropriate regulatory body regarding the use in competition horses.
As with all prescribed medication, Trimethoprim + Sulfonamide should only be given to the horse for which it was prescribed.
It should be given only for the condition for which it was prescribed.
This is just a summary of information about Trimethoprim + Sulfonamide. If you have any questions or concerns about this product or for the condition it was prescribed, please contact your veterinarian.